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Loreclezole hydrochloride

Cat. No. M6915

All AbMole products are for research use only, cannot be used for human consumption.

Loreclezole hydrochloride Structure

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Quality Control & Documentation
Biological Activity

Loreclezole hydrochloride is a subtype-selective GABAA receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. Also acts as a negative modulator at a novel regulatory site, enhancing GABAA receptor sensitization. Inhibits homomeric ρ1 GABAC receptors.

Chemical Information
Molecular Weight 311
Formula C10H6Cl3N3.HCl
CAS Number 117857-45-1
Solubility (25°C) DMSO 1.37 mg/mL (with gentle warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] McGaraughty, et al. Mol Pain. TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats.

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Keywords: Loreclezole hydrochloride supplier, inhibitors, activators

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