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Lopinavir (ABT-378) is an antiretroviral of the protease inhibitor class. Lopinavir potently inhibited wild-type and mutant HIV protease (Ki = 1.3 to 3.6 pM). Lopinavir (ABT-378) also produced negligible or weak inhibition of human CYP1A2, 2B6, 2C9, 2C19 and 2D6. Lopinavir (ABT-378) blocked the replication of laboratory and clinical strains of HIV type 1 (50% effective concentration [EC50], 0.006 to 0.017 microM), and maintained high potency against mutant HIV selected by ritonavir in vivo (EC50, 50-fold after 8 h.
Nat Commun. 2025 Jan 14;16(1):617.
Oncogenic role of RARG rearrangements in acute myeloid leukemia resembling acute promyelocytic leukemia
Lopinavir purchased from AbMole
| Molecular Weight | 628.8 |
| Formula | C37H48N4O5 |
| CAS Number | 192725-17-0 |
| Solubility (25°C) | DMSO 110 mg/mL Ethanol 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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Products are for research use only. Not for human use. We do not sell to patients.
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