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Lomitapide

Cat. No. M2208

All AbMole products are for research use only, cannot be used for human consumption.

Lomitapide Structure
Synonym:

AEGR-733, BMS-201038

Size Price Availability Quantity
5mg USD 70 In stock
10mg USD 120 In stock
50mg USD 330 In stock
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Quality Control & Documentation
Biological Activity

Lomitapide is a small-molecule, microsomal triglyceride transfer protein (MTP) inhibitor, for the treatment of both familial and primary hypercholesterolemia. Oral, once-daily lomitapide will be targeted at patients resistant to HMG-CoA reductase inhibitors (statins) either due to abnormalities in liver function or to discontinuation because of muscle pain.

Chemical Information
Molecular Weight 693.72
Formula C39H37F6N3O2
CAS Number 182431-12-5
Solubility (25°C) DMSO 47 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Perry CM. Am J Cardiovasc Drugs. Lomitapide: a review of its use in adults with homozygous familial hypercholesterolemia.

[2] Am J Cardiovasc Drugs. Lomitapide.

[3] Sulsky R, et al. Bioorg Med Chem Lett. 5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP.

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Keywords: Lomitapide, AEGR-733, BMS-201038 supplier, inhibitors, activators

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