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Lometrexol (DDATHF) hydrate, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol hydrate can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol hydrate has anticancer activity. Lometrexol hydrate also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor.
| Molecular Weight | 461.47 |
| Formula | C21H27N5O7 |
| CAS Number | 1435784-14-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 40 mg/mL (Need ultrasonic and warming) |
| Storage | 4°C, dry, sealed |
| Related Antifolate Products |
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| Pyrimethamine
Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM. |
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