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Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexes containing a 1,2-bis(aminomethyl)cyclobutane stable ligand and lactic acid as the leaving group. Lobaplatin influences the expression of the c-myc gene, which is involved in oncogenesis, apoptosis and cell proliferation. Lobaplatin has activity in a wide range of preclinical tumour models and appears to overcome tumour resistance to cisplatin and carboplatin in some of these models. In the body, lobaplatin remains largely intact until removed by glomerular filtration.
This product is not recommended to be dissolved in dimethylsulfoxide (DMSO). Lobaplatin should not be dissolved in sodium chloride solution, which induces its degradation.
| Molecular Weight | 397.33 |
| Formula | C9H18N2O3Pt |
| CAS Number | 135558-11-1 |
| Solubility (25°C) | Water 45 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] M J McKeage, et al. Expert Opin Investig D rvgs. Lobaplatin: a new antitumour platinum d rvg
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