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LM11A 31 dihydrochloride is a nonpeptide p75NTR ligand; blocks p75-mediated cell death and also increases proliferation and survival of hippocampal neural progenitors. Exhibits no effect on nerve growth factor (NGF) binding to TrkA. Prevents and reverses atrophy of cholinergic neurites, as well as reversing Alzheimer's Disease (AD) pathologies in mid- to late-stage AD mice models. Shown to promote functional recovery in a mouse model of spinal cord injury. Orally available and brain penetrant.
| Molecular Weight | 316.27 |
| Formula | C12H25N3O2.2HCl |
| CAS Number | 1243259-19-9 |
| Solubility (25°C) | DMSO 31.63 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Lee and Mapp. J Biol Chem. Transcriptional switches: chemical approaches to gene regulation.
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