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LIT-001 free base is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM). LIT-001 free base improves social interaction in a mouse model of autism.
| Molecular Weight | 531.67 |
| Formula | C28H33N7O2S |
| CAS Number | 2245072-20-0 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Related Oxytocin Receptor Products |
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| Cligosiban
Cligosiban (PF-3274167) is a high-affinity, high oral bioavailability and good brain-penetrant nonpeptide oxytocin receptor (OTR) antagonist, with Ki of 9.5 nM. |
| Oxytocin acetate
Oxytocin acetate, a mammalian neurohypophysial hormone, is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma. |
| Carbetocin
Carbetocin is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin can crosse the blood-brain barrier and produces antidepressant-like activity via activation of oxytocin receptors in the CNS. |
| L-368,899 hydrochloride
L-368,899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC50s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively. |
| Atosiban
Atosiban (RW22164; RWJ22164) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research. |
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