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Lirentelimab

Cat. No. M25068

All AbMole products are for research use only, cannot be used for human consumption.

Lirentelimab Structure
Synonym:

AK002; Anti-Siglec-8 Reference Antibody

Price and Availability

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Quality Control & Documentation
Biological Activity

Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis.

Chemical Information
CAS Number 2283348-97-8
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Stephen D Anesi, et al. J Allergy Clin Immunol. Lirentelimab for severe and chronic forms of allergic conjunctivitis

[2] Sabine Altrichter, et al. J Allergy Clin Immunol. An open-label, proof-of-concept study of lirentelimab for antihistamine-resistant chronic spontaneous and inducible urticaria

[3] Marcus Maurer, et al. J Allergy Clin Immunol Pract. Biologics for the Use in Chronic Spontaneous Urticaria: When and Which

[4] Evan S Dellon, et al. Ann Allergy Asthma Immunol. Biologics in eosinophilic gastrointestinal diseases

[5] Mitchell M Pitlick, et al. World Allergy Organ J. Current and emerging biologic therapies targeting eosinophilic disorders

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Keywords: Lirentelimab, AK002; Anti-Siglec-8 Reference Antibody supplier, Apoptosis, inhibitors, activators

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