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Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that may be used in studies related to type 2 diabetes. Liraglutide binds to the same receptors as does the endogenous metabolic hormone GLP-1. Liraglutide activated AMPK/SREBP1 pathway in oxLDL-stimulated Raw264.7 cells.
| Cell Experiment | |
|---|---|
| Cell lines | Raw264.7 macrophage cells |
| Preparation method | Raw264.7 macrophage cells are cultured in DMEM supplemented with 10% fetal bovine serum in a humidified 37°C incubator with 5% CO2. The cells are incubated with oxLDL (50 μg/mL), Liraglutide (0.1, 0.5, 1 and 2 nmol/L) or Exendin-3 (9-39) (1, 10 and 100 nM) alone, or in combination. |
| Concentrations | 0.1, 0.5, 1 and 2 nmol/L |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 3751.20 |
| Formula | C172H265N43O51 |
| CAS Number | 204656-20-2 |
| Form | Solid |
| Solubility (25°C) | Water 4 mg/mL (ultrasonic and warming and adjust pH to 4 with HCl) 0.1 M NaOH: 12 mg/mL (adjust pH to 8 with 0.1 M NaOH) |
| Storage | -20°C, dry, sealed |
| Related GLP Receptor Products |
|---|
| Dulaglutide (Activated main chain)
Dulaglutide (Activated main chain) is a glucagon-like peptide-1 receptor agonist (GLP-1 agonist) consisting of GLP-1(7-37) covalently linked to an Fc fragment of human IgG4. |
| Shanzhiside-methylester
Shanzhiside Methyl ester was isolated from Lactobacillus rotaformis. Shanzhiside Methyl ester, a small molecule glucagon-like peptide 1 (GLP-1 receptor) agonist, has the ability to induce anti-abnormal pain tolerance. |
| Tirzepatide hydrochloride
Tirzepatide Hydrochloride is a glucose-dependent insulin-stimulating peptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. |
| PF-07081532
PF-07081532 is a next-generation orally active GLP-1 receptor agonist. |
| BETP
BETP is an agonist of glucagon-like peptide-1 (GLP-1) receptor, with EC50s of 0.66 and 0.755 μM for human and rat GLP-1 receptor, respectively. |
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