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Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM.
| Molecular Weight | 352.47 |
| Formula | C20H32O5 |
| CAS Number | 89663-86-5 |
| Form | Liquid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] No authors listed. Arerugi. [Lipoxin A4]
[5] T H Lee. Thorax. Lipoxin A4: a novel anti-inflammatory molecule?
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