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Lin28-let-7 antagonist 1 

Cat. No. M27769

All AbMole products are for research use only, cannot be used for human consumption.

Lin28-let-7 antagonist 1  Structure

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Biological Activity

Lin28-let-7 antagonist 1 (compound 1632) is a potent antagonist of Lin28/pre-let-7 interaction. Lin28-let-7 antagonist 1 inhibits Lin28A binding to pre-let-7a-2, with an IC50 of 8 μM. Lin28-let-7 antagonist 1 inhibits proliferation in human cancer cells.

Chemical Information
Molecular Weight 281.31
Formula C15H15N5O
CAS Number 108825-65-6
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Georg L Goebel, et al. Eur J Med Chem. Small molecules with tetrahydroquinoline-containing Povarov scaffolds as inhibitors disrupting the Protein-RNA interaction of LIN28-let-7

[2] Wan Gi Byun, et al. Chembiochem. Discovery of Small-Molecule Modulators of Protein-RNA Interactions by Fluorescence Intensity-Based Binding Assay

[3] Yanlian Chen, et al. Cancer Immunol Res. LIN28/ let-7/PD-L1 Pathway as a Target for Cancer Immunotherapy

[4] Martina Roos, et al. ACS Chem Biol. A Small-Molecule Inhibitor of Lin28

[5] Liem H Nguyen, et al. Transl Pediatr. Lin28 and let-7 in cell metabolism and cancer

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Keywords: Lin28-let-7 antagonist 1  supplier, inhibitors, activators

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