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Limonin is a potent inhibitor of CYP3A4 with an IC50 of 6.2 μM. Limonin inhibits HIV-1 with an EC50 of 60.0 μM. Limonin induces human colon adenocarcinoma cells apoptosis with an IC50 of 54.74 μM. Limonin, a triterpenoid rich in citrus fruits, has antiviral and anti-tumor activities.
| Molecular Weight | 470.51 |
| Formula | C26H30O8 |
| CAS Number | 1180-71-8 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL (ultrasonic and warming) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Yunyi Chen, et al. Limonin induces apoptosis of HL-60 cells by inhibiting NQO1 activity
[5] Shunming Fan, et al. Limonin: A Review of Its Pharmacology, Toxicity, and Pharmacokinetics
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