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LGX818 is a highly potent RAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing B-RAF(V600E) with EC50 of 4 nM.
| Molecular Weight | 540.01 |
| Formula | C22H27ClFN7O4S |
| CAS Number | 1269440-17-6 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Rahul Seth, et al. Systemic Therapy for Melanoma: ASCO Guideline
[5] Paola Savoia, et al. Targeting the ERK Signaling Pathway in Melanoma
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