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Lexatumumab

Cat. No. M25256

All AbMole products are for research use only, cannot be used for human consumption.

Lexatumumab Structure
Synonym:

HGS-ETR 2 ETR2-ST01 Anti-Human ERBB3 Recombinant Antibody

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Quality Control & Documentation
Biological Activity

Lexatumumab (HGS-ETR 2) is a human agonistic TRAIL receptor 2 (TRAIL-R2, DR5, APO-2) IgG4κ type monoclonal antibody. Lexatumumab induces apoptosis in malignant mesothelioma. Lexatumumab can be used for malignant pleural mesothelioma (MPM) research.

Chemical Information
CAS Number 845816-02-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Arvind Chopra. 111In-Labeled lexatumumab

[2] Arvind Chopra. 99mTc-Labeled lexatumumab

[3] Xiu-Xian Wu, et al. Clin Cancer Res. Enhancement of lexatumumab-induced apoptosis in human solid cancer cells by Cisplatin in caspase-dependent manner

[4] Patrizia Marini. Curr Opin Mol Ther. Drυg evaluation: lexatumumab, an intravenous human agonistic mAb targeting TRAIL receptor 2

[5] Liang Zhang, et al. Cancer Lett. Lexatumumab (TRAIL-receptor 2 mAb) induces expression of DR5 and promotes apoptosis in primary and metastatic renal cell carcinoma in a mouse orthotopic model

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Keywords: Lexatumumab, HGS-ETR 2 ETR2-ST01 Anti-Human ERBB3 Recombinant Antibody supplier, Apoptosis, inhibitors, activators

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