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Levofloxacin is a synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. Levofloxacin inhibits bacterial type II topoisomerases, topoisomerase IV and DNA gyrase. Levofloxacin, like other fluoroquinolones, inhibits the A subunits of DNA gyrase, two subunits encoded by the gyrA gene. This results in strand breakage on a bacterial chromosome, supercoiling, and resealing; DNA replication and transcription is inhibited.
| Molecular Weight | 361.37 |
| Formula | C18H20FN3O4 |
| CAS Number | 100986-85-4 |
| Solubility (25°C) | DMSO 10 mg/mL Water 7 mg/mL |
| Storage | 2-8°C, protect from light, sealed |
[1] Andrejs Sitovs, et al. Levofloxacin in veterinary medicine: a literature review
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