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Leupeptin hemisulfate hemisulfate is the reversible inhibitor of lysosomal serine and cysteine proteinases; Leupeptin; inhibition of cathepsin B(Ki=6 nM), calpain(Ki=10 nM), trypsin (Ki=35 nM), plasmin (Ki=3.4 μM) and kallikrein (Ki=19 μM) had no effect on chymotrypsin, elastase, renin, or pepsin.
Cell Death Dis. 2021 Oct 16;12(11):955.
Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression
Leupeptin hemisulfate purchased from AbMole
| Molecular Weight | 475.59 |
| Formula | C20H38N6O4.½H2SO4 |
| CAS Number | 103476-89-7 |
| Solubility (25°C) | Water 10 mg/mL DMSO 60 mg/mL |
| Storage | -20°C, dry, sealed |
[3] L C Morejohn, et al. Inhibition of plant cell proteolytic activities that degrade tubulin
| Related Cathepsin Products |
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| N-Ethylmaleimide
N-Ethylmaleimide (NEM) is a cysteine protease inhibitor. |
| Odanacatib
Odanacatib (MK-0822) is a potent and reversible covalent inhibitor of CathepsinK (CatK) with an IC50 of 0.2 nM/1 nM for human/rabbit cathepsin B, L, and S and is highly selective. |
| Balicatib
Balicatib is a potent and selective inhibitor of cathepsin K; 10-100-fold more potent in cell-based enzyme occupancy assays than against cathepsin B, L, and S. |
| Aloxistatin
Aloxistatin (E64d) is an irreversible and membrane-permeable cysteine protease inhibitor. |
| Cathepsin Inhibitor 1
Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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