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Leucomethylene blue mesylate

Cat. No. M14554

All AbMole products are for research use only, cannot be used for human consumption.

Leucomethylene blue mesylate Structure
Synonym:

TRx0237 mesylate; Methylene blue leuco base mesylate

Size Price Availability Quantity
5mg USD 50 In stock
10mg USD 71 In stock
25mg USD 145 In stock
50mg USD 214 In stock
100mg USD 328 In stock
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Quality Control & Documentation
Biological Activity

Leucomethylene blue (TRx0237) mesylate, an orally active second-generation tau protein aggregation inhibitor (Ki of 0.12 μM), could be used for the study of Alzheimer's Disease. Leucomethylene blue mesylate is a common reduced form of Methylene Blue, Methylene Blue is a member of the thiazine class of dyes.

Chemical Information
Molecular Weight 477.62
CAS Number 1236208-20-0
Solubility (25°C) DMSO 90 mg/mL
Water 83.33 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Karima Schwab, et al. Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine

[2] Renato X Santos, et al. HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine

[3] Constantin Kondak, et al. Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine

[4] Wei-Feng Gui, et al. In Vitro and in Vivo Effect of MAPK Signal Transduction Pathway Inhibitors on Echinococcus multilocularis

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Keywords: Leucomethylene blue mesylate, TRx0237 mesylate; Methylene blue leuco base mesylate supplier, Amyloid, inhibitors, activators

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