All AbMole products are for research use only, cannot be used for human consumption.
Letrozole is an orally active, potent, selective, nonsteroidal, third-generation aromatase (CYP19A1) inhibitor, a synthetic benzyltriazole derivative, which is used in the construction of animal models of polycystic ovary syndrome (PCOS), as well as in studies related to postoperative hormone-responsive breast cancer.
EMBO Mol Med. 2023 Dec.
MYSM1 acts as a novel co-activator of ERα to confer antiestrogen resistance in breast cancer
Letrozole purchased from AbMole
BioRxiv. 2022 Dec 23;521780.
MYSM1 co-activates ERα action via histone and non-histone deubiquitination to confer antiestrogen resistance in breast cancer
Letrozole purchased from AbMole
J Steroid Biochem Mol Biol. 2013 Nov;138:54-62.
Effect of androgens on different breast cancer cells co-cultured with or without breast adipose fibroblasts
Letrozole purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | Human breast cancer cells MCF-7 |
| Preparation method | Seeding cells in duplicate at 5,000 to 10,000 cells per well in 24-well plates. The day after plating,adding different concentrations of Letrozole . At the end of incubation, trypsinizating cells and placing in Isotone solution and counting immediately using a Coulter particle-counter. |
| Concentrations | ~100 nM |
| Incubation time | 1 days |
| Animal Experiment | |
|---|---|
| Animal models | Human breast carcinoma xenografts MCF-7 with human aromatase gene (MCF-7Ca) |
| Formulation | 0.5% (w/v) solution of carboxymethylcellulos |
| Dosages | 20 mg/kg/day |
| Administration | orally administered by gavage once every 2 days |
| Molecular Weight | 285.30 |
| Formula | C17H11N5 |
| CAS Number | 112809-51-5 |
| Solubility (25°C) | DMSO ≥ 45 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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