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LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively.
| Molecular Weight | 432.56 |
| Formula | C25H32N6O |
| CAS Number | 1204975-42-7 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Jean Y Tang, et al. Semin Cutan Med Surg. Emerging treatments and signaling pathway inhibitors
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SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM. |
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