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Leniolisib (CDZ173) phosphate is a first-in-class, potent and selective PI3Kδ inhibitor with an IC50 value of 11 nM.Leniolisib is more selective for PI3K-δ than PI3K-α (28-fold), PI3K-β (43-fold) and PI3K-γ (257-fold). -γ (257-fold). In a cellular assay, Leniolisib decreased pAKT pathway activity and inhibited the proliferation and activation of B and T cell subsets.
| Molecular Weight | 548.45 |
| Formula | C21H28F3N6O6P |
| CAS Number | 1354691-97-6 |
| Form | Solid |
| Storage | -20°C, dry, sealed |
[1] No authors listed. Am J Health Syst Pharm. Leniolisib Phosphate
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