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LDN-211904 oxalate is a potent and selective EphB3 inhibitor with an IC50 of 0.079 µM.LDN-211904 oxalate showed good metabolic stability in mouse liver microsomes.LDN-211904 oxalate was shown to be effective in inhibiting STAT3-activated CSC stemness in combination with cetuximab.
| Molecular Weight | 444.87 |
| Formula | C21H21ClN4O5 |
| CAS Number | 1198408-78-4 |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Ephrin Receptor Products |
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| ALW-II-41-27
ALW-II-41-27 is a Eph receptor tyrosine kinase inhibitor with an IC50 of 11 nM for EPHA2. |
| NVP-BHG712 isomer
NVP-BHG712 isomer, a regioisomer of NVP-BHG712, shows conserved non-bonded binding to EPHA2 and EPHB4. |
| ALW-II-49-7
ALW-II-49-7 is a selective EphB2 kinase inhibitor with an EC50 value of 40 nM in cell. |
| 123C4
123C4 is a potent, selective and competitive agonist of the receptor tyrosine kinase EPHA4, with a Ki value of 0.65 μM. |
| Urolithin D
Urolithin D is competitive and reversible antagonist of EphA receptors. |
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