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LDN-193189 dihydrochloride is a selective BMP signaling inhibitor, and inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, 200-fold selectivity for BMP versus TGF-β. LDN-193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva. LDN-193189 targets GDF8 induced Smad2/3 signaling and repression of myogenic transcription factors. LDN-193189 (0.05, 0.5, 5 μM) efficiently inhibits GDF8 induced Smad3/4 reporter gene activity.
Patent. CN120248011A 2025 Jul 04; .
Patent. CN120248011A
LDN-193189 dihydrochloride purchased from AbMole
| Molecular Weight | 479.40 |
| Formula | C25H24Cl2N6 |
| CAS Number | 1435934-00-1 |
| Solubility (25°C) | Water 11 mg/mL DMSO 8 mg/mL (ultrasonic and warming) |
| Storage | 4°C, dry, sealed |
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RepSox (ALK5 Inhibitor II) is a potent and ATP-competitive inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively). |
| LDN-193189
LDN-193189 is a highly potent small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3. |
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