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Lazertinib, also known as YH-25448 and GNS-1480, is an oral active, highly potent, mutant-selective and irreversible EGFR Tyrosine-kinase inhibitors (TKIs) targets both the T790M mutation and activating EGFR mutations while sparing wild type-EGFR. Lazertinib (YH25448) has good blood brain barrier (BBB) penetration property.
| Molecular Weight | 554.64 |
| Formula | C30H34N8O3 |
| CAS Number | 1903008-80-9 |
| Solubility (25°C) | DMSO 6 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] No authors listed. Cancer Discov. Lazertinib Is Safe and Effective in Non-Small Cell Lung Cancer
[2] Sohita Dhillon. Correction to: Lazertinib: First Approval
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