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Lauroyl-L-carnitine chloride is an amphiphilic compound capable of forming micelles. Lauroyl-L-carnitine chloride enhances absorption by reducing solution surface tension, thereby increasing the dissolution and diffusion of compounds and bioactive molecules within the gastrointestinal tract of experimental animals. Furthermore, as a transport carrier for long-chain fatty acids (such as lauric acid), lauroyl-L-carnitine chloride facilitates the entry of fatty acids into mitochondria for β-oxidation. Lauroyl-L-carnitine chloride can be used as an absorption enhancer.
| Cell Experiment | |
|---|---|
| Cell lines | BMDM cells |
| Preparation method | Primary bone marrow derived macrophages (BMDM) were treated with media alone for unpolarized macrophages “M0", 5 ng/mL LPS plus 10 ng/mL interferon gamma (IFNγ) to drive the pro-inflammatory “M1" phenotype, or 20 and 200 µM doses of lauroyl L-carnitine (“LC") for 24 hours. |
| Concentrations | 20 and 200 µM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Female C57BL / 6 mice |
| Formulation | Not mentioned |
| Dosages | 3 mg/kg |
| Administration | Orally administered |
| Molecular Weight | 379.96 |
| Formula | C19H38ClNO4 |
| CAS Number | 6919-91-1 |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage | 4°C, dry, sealed |
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