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Larotaxel

Cat. No. M38848

All AbMole products are for research use only, cannot be used for human consumption.

Larotaxel Structure

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Quality Control & Documentation
Biological Activity

Larotaxel (XRP9881) exerts its cytotoxic effect by promoting tubulin assembly and stabilizing microtubules, ultimately leading to cell death by apoptosis. It presents the ability to cross the blood brain barrier and has a much lower affinity for P-glycoprotein 1 than Docetaxel.

Chemical Information
Molecular Weight 831.9
Formula C45H53NO14
CAS Number 156294-36-9
Form Solid
Solubility (25°C) DMSO ≥ 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Xueqi Li et al. Small. Nanostructure of Functional Larotaxel Liposomes Decorated with Guanine-Rich Quadruplex Nucleotide-Lipid Derivative for Treatment of Resistant Breast Cancer

[2] Sumei Ren et al. Eur J Med Chem. Synthesis and biological evaluation of novel larotaxel analogues

[3] Xiaoming Liang et al. J Pharm Anal. Degradation kinetics of larotaxel and identification of its degradation products in alkaline condition

[4] Cora N Sternberg et al. Oncology. Larotaxel with Cisplatin in the first-line treatment of locally advanced/metastatic urothelial tract or bladder cancer: a randomized, active-controlled, phase III trial (CILAB)

[5] Otto Metzger-Filho et al. Expert Opin Investig Drugs. Larotaxel: broadening the road with new taxanes

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Keywords: Larotaxel supplier, Apoptosis, inhibitors, activators

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