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Laniquidar

Cat. No. M29072

All AbMole products are for research use only, cannot be used for human consumption.

Laniquidar Structure
Synonym:

R101933

Price and Availability

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Quality Control & Documentation
Biological Activity

Laniquidar (R101933) is a noncompetitive, third generation P-glycoprotein (P-gp) inhibitor with an IC50 of 0.51 μM. Laniquidar can be used for modulating multidrug resistance transporters. Laniquidar can also be used for studying acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Laniquidar has limited oral bioavailability.

Chemical Information
Molecular Weight 584.71
Formula C37H36N4O3
CAS Number 197509-46-9
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Femke E Froklage, et al. J Nucl Med. Quantification of 11C-Laniquidar Kinetics in the Brain

[2] Andrey Postnov, et al. J Nucl Med. Radiation dose of the P-glycoprotein tracer 11C-laniquidar

[3] Stina Syvänen, et al. Nucl Med Biol. [11C]quinidine and [11C]laniquidar PET imaging in a chronic rodent epilepsy model: impact of epilepsy and drug-responsiveness

[4] Lieselotte Moerman, et al. Nucl Med Biol. The influence of mass of [11C]-laniquidar and [11C]-N-desmethyl-loperamide on P-glycoprotein blockage at the blood-brain barrier

[5] Gert Luurtsema, et al. Nucl Med Biol. Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats

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Keywords: Laniquidar, R101933 supplier, P-glycoprotein, inhibitors, activators

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