All AbMole products are for research use only, cannot be used for human consumption.
Lamotrigine is a novel anticonvulsant compound for inhibition of 5-hydroxytryptamine (5-HT) uptake in both human platelets and rat brain synaptosomes with IC50 of 240 μM and 474 μM, respectively. Lamotrigine inhibits the synaptosomal uptake of noradrenaline and dopamine with IC50 of 239 μM and 322 μM, respectively. Lamotrigine is believed to mediate its anticonvulsant activity by the use- and voltage-dependent blockade of Na+ channels. Lamotrigine may also be useful in the treatment of bipolar illness with efficacy against depressive breakthroughs and rapid cycling bipolar disorder. The reduction in the uptake of label caused by 1 mM lamotrigine incubated in the presence of 10 nM 5-HT is reversed by increasing the substrate concentration 10-fold. The inhibition of the p-chloroamphetamine-induced 5-HT syndrome in rats suggests that lamotrigine also inhibits 5-HT uptake. Lamotrigine is a new generation broad-spectrum anticonvulsant.
| Molecular Weight | 256.09 |
| Formula | C9H7Cl2N5 |
| CAS Number | 84057-84-1 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Ahmed Naguy, et al. Lamotrigine Uses in Psychiatric Practice
[2] Mike J Crawford, et al. Lamotrigine for people with borderline personality disorder: a RCT
| Related Sodium Channel Products |
|---|
| Riluzole
Rilutek is a sodium channel protein inhibitor and a new mental compound, which has anticonvulsant, hypnotic, antianxiety, antiischemia and anesthesia properties. Riluzole belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM. |
| A-803467
A-803467 is a potent and selective Nav1.8 sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50 = 140 nM). |
| Oxcarbazepine
Oxcarbazepine is an anticonvulsant and mood-stabilizing compound. |
| Ambroxol hydrochloride
AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. |
| Camostat mesylate
Camostat mesylate is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
