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Labetuzumab govitecan

Cat. No. M24697

All AbMole products are for research use only, cannot be used for human consumption.

Labetuzumab govitecan Structure
Synonym:

IMMU 130 hMN-14-SN-38

Size Price Availability Quantity
100ug USD 420 In stock
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Quality Control & Documentation
Biological Activity

Labetuzumab govitecan (IMMU 130) is an Anti-CEACAM5/SN-38 antibody-drug conjugate (ADC). Labetuzumab govitecan consists of the antibody Labetuzumab, SN-38, and a pH-sensitive Linker. Labetuzumab govitecan can be used for research of cancers, such as colorectal cancer.

Chemical Information
CAS Number 1469876-18-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Diana C DeLucia, et al. Clin Cancer Res. Regulation of CEACAM5 and Therapeutic Efficacy of an Anti-CEACAM5-SN38 Antibody-drυg Conjugate in Neuroendocrine Prostate Cancer

[2] Wenjuan Dong, et al. Eur J Med Chem. Antibody-drυg conjugates of 7-ethyl-10-hydroxycamptothecin: Sacituzumab govitecan and labetuzumab govitecan

[3] Robert M Sharkey, et al. Mol Cancer Ther. Selective and Concentrated Accretion of SN-38 with a CEACAM5-Targeting Antibody-Drυg Conjugate (ADC), Labetuzumab Govitecan (IMMU-130)

[4] Manjulika Das. Lancet Oncol. Labetuzumab govitecan in metastatic colorectal cancer

Related Drug-Linker Conjugates for ADC Products
Mc-Val-Cit-PABC-PNP

Mc-Val-Cit-PABC-PNP is a histone-cleavable peptide linker for antibody-drug couplings (ADCs) that can be used for the synthesis of ADCs such as Brentuximab vedotin.

DM1-SMCC

DM1-SMCC is DM1 with a reactive linker SMCC, which can react with antibody to make ADC.

CL2A-SN-38

CL2A-SN-38 is a SN38 derivative with a peptide-linker which can easily react with antibody to form an ADC.

BS3 (bis(sulfosuccinimidyl)suberate)

BS3 (bis(sulfosuccinimidyl)suberate) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Sulfo-SMCC sodium

Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.

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Keywords: Labetuzumab govitecan, IMMU 130 hMN-14-SN-38 supplier, Drug-Linker Conjugates for ADC, inhibitors, activators

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