All AbMole products are for research use only, cannot be used for human consumption.
L-NAME hydrochloride is a nonselective inhibitor of nitric oxide synthetases (NOS) for nNOS, eNOS, and iNOS, with K<sub>i</sub> of 15 nM, 39 nM and 4.4 μM, respectively.
Neurotherapeutics. 2023 Dec;10.011.
Nicotinamide riboside, pterostilbene and ibudilast protect motor neurons and extend survival in ALS mice
L-NAME hydrochloride purchased from AbMole
Journal of Entomological Science. 2022 Mar 29;57 (2): 288–296.
Effect of a Nitric Oxide Synthase Inhibitor on Fighting Behavior of Male Crickets Velarifictorus aspersus (Orthoptera: Gryllidae) under Different Resource Conditions
L-NAME hydrochloride purchased from AbMole
Oxid Med Cell Longev. 2021 Jun 14;2021:6662225.
Impaired Autophagy Induced by oxLDL/ β 2GPI/anti- β 2GPI Complex through PI3K/AKT/mTOR and eNOS Signaling Pathways Contributes to Endothelial Cell Dysfunction
L-NAME hydrochloride purchased from AbMole
 |
Source | Oxid Med Cell Longev (2021). Figure 5. (Abmole Bioscience, USA) |
| Method | Cell Culture and Treatment | |
| Cell Lines | HUVECs and bEnd.3 cells | |
| Concentrations | 100 μM | |
| Incubation Time | 4 h | |
| Results | We found that LY294002, AZD5363, rapamycin, and L-NAME pretreatment could significantly upregulate the expression of LC3-II, while downregulating the expression of p62 compared with the oxLDL/β2GPI/anti-β2GPI complex alone group |
| Cell Experiment | |
|---|---|
| Cell lines | H9C2 cells |
| Preparation method | H9C2 cells were exposed to hypoxia (2%O2; 4 h) or normoxic medium (21%O2; 4 h). After 4 h, culture medium was replaced with reoxygenated medium (21%O2 2 h) for H/R and normoxia controls, or hypoxic medium (2%O2; 2 h) in the presence and absence of 50 µM MnTBap or 100 µM L-NAME and then further incubated for 2 h in the presence of MTT reagent. |
| Concentrations | 100 µM |
| Incubation time | 2 h |
| Animal Experiment | |
|---|---|
| Animal models | Male Sprague-Dawley rats |
| Formulation | distilled water |
| Dosages | 40 mg/kg/day |
| Administration | i.v. |
| Molecular Weight | 269.69 |
| Formula | C7H15N5O4.HCl |
| CAS Number | 51298-62-5 |
| Solubility (25°C) | Water ≥ 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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