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L-Dopa ethyl ester is a precursor compound of levodopa, which has a high gastric solubility. The drug is rapidly hydrolyzed to levodopa in the gastrointestinal tract by nonspecific esterase. Levodopa-carbidopa treatment was well tolerated, but did not show superior efficacy compared to standard levodopa-carbidopa treatment. L-dopa should have significant cerebral penetration after injection.
| Molecular Weight | 225.24 |
| Formula | C11H15NO4 |
| CAS Number | 37178-37-3 |
| Solubility (25°C) | Water: ≥12 mg/mL at warmed to 60 °C |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] J A Fix, et al. Short-chain alkyl esters of L-dopa as prodrugs for rectal absorption
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