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L-701324

Cat. No. M4956

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L-701324 Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 39 In stock
5mg USD 34 In stock
10mg USD 56 In stock
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Quality Control & Documentation
Biological Activity

L-701324 is a potent anticonvulsant compound that reduces the propensity to activate the mesolimbic dopaminergic system in rodents. L-701324 showed beneficial effects in animal models of Parkinson's rigidity, but not in animal models of Parkinson's dyskinesia. L-701324 (2.5-40 mg/kg, I.P.) dose-dependently reduced enhanced muscle tone from haloperidol (1-5 mg/kg, I.P.).

Chemical Information
Molecular Weight 363.79
Formula C21H14ClNO3
CAS Number 142326-59-8
Form Solid
Solubility (25°C) DMSO 36 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ling Liu, et al. Antidepressant-like activity of L-701324 in mice: A behavioral and neurobiological characterization

[2] Nobuhiro Kawai, et al. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus

[3] Christina Zellinger, et al. Pre-treatment with the NMDA receptor glycine-binding site antagonist L-701,324 improves pharmacosensitivity in a mouse kindling model

[4] Kenneth W Perry, et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas

[5] J Konieczny, et al. L-701,324, a selective antagonist at the glycine site of the NMDA receptor, counteracts haloperidol-induced muscle rigidity in rats

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