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KY02111 is a widely used small molecule that boosts cardiomyogenesis. Chemical genetics of KY02111 identified squalene synthase (SQS) as a molecular target of KY02111. By disrupting the interaction of SQS with cardiac ER-membrane protein TMEM43, KY02111 impairs TGFβ/SMAD signaling and recapitulates the clinical mutation of TMEM43 that causes an inherited heart disease.
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Source | Exp Eye Res (2015). Figure 2. KY02111 |
| Method | Western blot | |
| Cell Lines | HTM cells | |
| Concentrations | 10 μM | |
| Incubation Time | 8 days | |
| Results | When HTM cells were treated with SFRP1 (0.5 μg/mL) and a small molecular inhibitor (10 μM KY02111), there was a substantial increase in T41 phosphorylation, indicating Wnt inhibition |
| Molecular Weight | 376.86 |
| Formula | C18H17ClN2O3S |
| CAS Number | 1118807-13-8 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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