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KY-226 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with IC50 of 0.25 μM, which protects neurons from cerebral ischemic injury. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively. KY-226 (0.3-10 μM) increases the phosphorylated insulin receptor (pIR) produced by insulin in human hepatoma-derived cells.
In vivo, KY-226 (10-30 mg/kg/day; oral; for 4 weeks) treatment in male db/db mice significantly reduces plasma glucose and triglyceride levels as well as hemoglobin A1c values without increasing body weight gain.
| Molecular Weight | 481.67 |
| Formula | C27H31NO3S2 |
| CAS Number | 1621673-53-7 |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Phosphatase Products |
|---|
| CCT007093
CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM. |
| Microcystin-LR
Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1. |
| Sal003
Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor. |
| Razuprotafib
Razuprotafib (AKB-9778) is an effective selective inhibitor of VE-PTP (HPTPß) catalytic activity (IC50=17 pM). |
| β-Glycerophosphate disodium salt hydrate
β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. |
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