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KS15 

Cat. No. M27678

All AbMole products are for research use only, cannot be used for human consumption.

KS15  Structure

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Biological Activity

KS15 is an inhibitor of the interactions between cryptochromes (CRYs: CRY1 and CRY2) and the CLOCK:BMAL1 heterodimer. KS15 impairs the feedback actions of CRYs on E-box-dependent transcription (EC50=4.9 μM) by CLOCK:BMAL1 heterodimer, an indispensable transcriptional regulator of the mammalian circadian clock. Anti-proliferative activity.

Chemical Information
Molecular Weight 420.3
Formula C20H22BrNO4
CAS Number 1033781-20-2
Form Liquid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage -20°C, dry, sealed
References

[1] Ilya A Solovev, et al. Clocks Sleep. Chronobiotics KL001 and KS15 Extend Lifespan and Modify Circadian Rhythms of Drosophila melanogaster

[2] Jaebong Jang, et al. Life Sci. The cryptochrome inhibitor KS15 enhances E-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex

[3] Z Zhu, et al. Transbound Emerg Dis. Emergence of novel Seneca Valley virus strains in China, 2017

[4] Zhenhai Chen, et al. Virology. Construction and characterization of a full-length cDNA infectious clone of emerging porcine Senecavirus A

[5] Sung Kook Chun, et al. Biochem Biophys Res Commun. A synthetic cryptochrome inhibitor induces anti-proliferative effects and increases chemosensitivity in human breast cancer cells

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Keywords: KS15  supplier, inhibitors, activators

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