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Mocravimod (KRP-203) hydrochloride is a potent, orally active sphingosine receptor S1P1 and S1P4 agonist with EC50s of 1 nM and 10 nM, respectively, and may be used in studies related to ulcerative colitis (UC).
Biochem Biophys Res Commun. 2024 Apr 27;718:149981.
A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion
KRP-203 hydrochloride purchased from AbMole
 |
Source | Arterioscler Thromb Vasc Biol (2013). Figure 3. KRP-203 |
| Method | i.v. | |
| Cell Lines | LDL-R-/- mice | |
| Concentrations | 3.0 mg/kg | |
| Incubation Time | 16 weeks | |
| Results | In addition, reduced production of interleukin (IL)-2 and interferon (IFN)-γ, 2 cytokines released from activated CD4+ T cells in response to concanavalin A or phytohaemagglutinin, was noted in splenocytes obtained from KRP-203–treated mice |
| Molecular Weight | 480.45 |
| Formula | C24H26ClNO3S.HCl |
| CAS Number | 509088-69-1 |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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