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KRCA 0008

Cat. No. M6871

All AbMole products are for research use only, cannot be used for human consumption.

KRCA 0008 Structure

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Quality Control & Documentation
Biological Activity

KRCA 0008 is a potent Ack1 and anaplastic lymphoma kinase (ALK) dual inhibitor (IC50 values are 4 and 12 nM respectively). Inhibits lung cancer H3122 cell proliferation (IC50 = 80 nM). Attenuates H3122 cell xenograft tumor growth in mice. Orally bioavailable.

Chemical Information
Molecular Weight 609.12
Formula C30H37ClN8O4
CAS Number 1472795-20-2
Solubility (25°C) 1eq. HCl 60.91 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Gupta, et al. Cell. Identification of selective inhibitors of cancer stem cells by high-throughput screening.

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Keywords: KRCA 0008 supplier, inhibitors, activators

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