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KRA-533 is a potent KRAS agonist. KRA-533 binds to the GTP/GDP binding pocket in the KRAS protein to prevent GTP cleavage, resulting in the accumulation of constitutively active GTP-bound KRAS that triggers both apoptotic and autophagic cell death pathways in cancer cells.
| Molecular Weight | 314.18 |
| Formula | C13H16BrNO3 |
| CAS Number | 10161-87-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 250 mg/mL (ultrasonic) |
| Storage | Powder -20°C |
[1] Ke Xu, et al. Mol Cancer. Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy
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