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KPLH1130 is a pyruvate dehydrogenase kinase (PDK)-specific inhibitor that blocks macrophage polarization, attenuates inflammatory responses, and improves glucose tolerance in mice fed a high-fat diet.
| Molecular Weight | 283.28 |
| Formula | C15H13N3O3 |
| CAS Number | 906669-07-6 |
| Form | Solid |
| Solubility (25°C) | DMSO >100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PDHK Products |
|---|
| M77976
M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648 μM. M77976 is potential for the research of obesity and diabetes. |
| VER-246608
VER-246608 is a potent and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50s of 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively. |
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