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KNT-127 

Cat. No. M28066

All AbMole products are for research use only, cannot be used for human consumption.

KNT-127  Structure

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Quality Control & Documentation
Biological Activity

KNT-127 is a potent and selective δ-opioid receptor agonist effective by systemic administration. KNT-127 shows selectivity for the δ-receptor (Ki 0f 21.3, 0.16, 153 nM for opioid μ-, δ-, and κ-receptors, respectively). KNT-127 increases the release of dopamine and L-glutamate in the striatum, nucleus accumbens and median pre-frontal cortex.

Chemical Information
Molecular Weight 372.46
Formula C24H24N2O2
CAS Number 1256921-89-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Toshinori Yoshioka, et al. Neuropharmacology. KNT-127, a selective delta opioid receptor agonist, shows beneficial effects in the hippocampal dentate gyrus of a chronic vicarious social defeat stress mouse model

[2] Ayako Kawaminami, et al. Front Behav Neurosci. Selective δ-Opioid Receptor Agonist, KNT-127, Facilitates Contextual Fear Extinction via Infralimbic Cortex and Amygdala in Mice

[3] Zachariah Bertels, et al. Headache. A non-convulsant delta-opioid receptor agonist, KNT-127, reduces cortical spreading depression and nitroglycerin-induced allodynia

[4] Akiyoshi Saitoh, et al. Behav Brain Res. The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice

[5] Shunsuke Tanahashi, et al. Neuropharmacology. Novel δ1-receptor agonist KNT-127 increases the release of dopamine and L-glutamate in the striatum, nucleus accumbens and median pre-frontal cortex

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  Catalog
Abmole Inhibitor Catalog




Keywords: KNT-127  supplier, Opioid Receptor, inhibitors, activators

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