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KN-93 hydrochloride is a cell-permeable inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMK-II) with a Ki of 370 nM. KN-93 HCl inhibits fibroblast CaMK-II activity and cell growth in a dose-dependent manner, reversibly arrests cells in G1 and induces apoptosis. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations.
| Molecular Weight | 537.5 |
| Formula | C26H30Cl2N2O4S |
| CAS Number | 1956426-56-4 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related CaMK Products |
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| KN-62
KN-62 is a selective, cell permeable inhibitor of calcium/calmodulin-dependent kinase II (CaMKII; IC50 = 900 nM). |
| NH125
NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor. |
| KN-92 phosphate
KN-92 is an inactive analog of the CaM kinase II inhibitor KN-93. |
| A23187
Calcimycin (A-23187) is a calcium ionophore that induces Ca2+-dependent cell death by increasing intracellular calcium concentration. |
| KN-92
KN-92 is an inactive analog of the CaM kinase II inhibitor KN-93. |
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