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KN-92 is an inactive analog of the CaM kinase II inhibitor KN-93. KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM).
| Molecular Weight | 554.98 |
| Formula | C24H28ClN2O7PS |
| CAS Number | 1135280-28-2 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related CaMK Products |
|---|
| KN-62
KN-62 is a selective, cell permeable inhibitor of calcium/calmodulin-dependent kinase II (CaMKII; IC50 = 900 nM). |
| NH125
NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor. |
| A23187
Calcimycin (A-23187) is a calcium ionophore that induces Ca2+-dependent cell death by increasing intracellular calcium concentration. |
| KN-92
KN-92 is an inactive analog of the CaM kinase II inhibitor KN-93. |
| A 484954
A 484954 is a caM kinase III (eEF-2 kinase) inhibitor. |
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Products are for research use only. Not for human use. We do not sell to patients.
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