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KN-62 is a cell-permeable, reversible, and selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II). KN-62 is also a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM). KN-62 inhibits the growth of K562 cells in a dose-dependent manner. KN-62 could inhibit the Ca2+/CaM kinase II activity in vivo. However, KN-62 only slightly influenced PC secretion from type II cells stimulated by phorbol 12-myristate 13-acetate, terbutaline and ATP that are known to increase surfactant secretion via the protein kinase C and protein kinase A pathways. KN-62 affects the interaction between calmodulin and Ca2+/CaM kinase II following inhibition of this kinase activity by directly binding to the calmodulin binding site of the enzyme but does not affect the calmodulin-independent activity of already autophosphorylated (activated) enzyme.
| Molecular Weight | 721.84 |
| Formula | C38H35N5O6S2 |
| CAS Number | 127191-97-3 |
| Solubility (25°C) | DMSO: ≥ 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related CaMK Products |
|---|
| NH125
NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor. |
| KN-92 phosphate
KN-92 is an inactive analog of the CaM kinase II inhibitor KN-93. |
| A23187
Calcimycin (A-23187) is a calcium ionophore that induces Ca2+-dependent cell death by increasing intracellular calcium concentration. |
| KN-92
KN-92 is an inactive analog of the CaM kinase II inhibitor KN-93. |
| A 484954
A 484954 is a caM kinase III (eEF-2 kinase) inhibitor. |
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