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KML29 is an effective selective MAGL inhibitor with IC50 values of 15 nM, 43 nM and 5.9 nM in mice, rats and humans, respectively. KML29 has minimal cross-reaction with other central and peripheral serine hydrolases including FAAH.
| Molecular Weight | 549.42 |
| Formula | C24H21F6NO7 |
| CAS Number | 1380424-42-9 |
| Solubility (25°C) | DMSO ≥ 40 mg/mL |
| Storage | -20°C |
| Related MAGL Products |
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| JZL184
JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM. |
| JZL 195
JZL195 is an effective FAAH and MAGL inhibitor with IC50 of 2 nM and 4 nM, respectively. |
| JW 642
Jw642 is a highly effective selective monoacylglycerol lipase (MAGL) inhibitor with IC50 of 7.6 nM, 14 nM and 3.7 nM in mouse, rat and human meninges, respectively. |
| MJN110
MJN110 is an orally effective and selective inhibitor of monacylglycerol lipase (MAGL) with IC50 of 9.1 nM and 2.1 nM against hMAGL and 2-arachidonic triglyceride (2-AG), respectively. It has strong anti-hyperalgesia activity. |
| JJKK-048
JJKK-048 is a cell penetrant ultrapotent and highly selective inhibitor of monoacylglycerol lipase (MAGL) that exhibits a low cross-reactivity with other endocannabinoid targets. |
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