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KME-2780 is the orally active inhibitor for IRAK1 and IRAK4, with IC50 values of 19 nM and 0.5 nM, respectively. KME-2780 promotes differentiation of leukaemia stem/progenitor cells (LSPCs), upregulates CD38 expression, and induces heterogeneous morphological alterations. KME-2780 exhibits antitumour activity against AML cells in a mouse xenograft model.
| Molecular Weight | 333.43 |
| Formula | C20H23N5 |
| CAS Number | 2968466-26-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage | -20°C, protect from light |
| Related IRAK Products |
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CA-4948 is a selective, potent and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) that regulates IRAK4 function in the TLR and IL-1R signaling cascades. CA-4948 has good pharmacokinetic characteristics and antitumor activity in vitro and in vivo. |
| AS 2444697
AS 2444697 is a potent and selective IRAK4 inhibitor. |
| Zimlovisertib
PF06650833 (Zimlovisertib) is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4). |
| IRAK-1-4 Inhibitor I
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| Zabedosertib
Zabedosertib (BAY 1834845) is a selective, orally potent IRAK4 inhibitor with immunomodulatory and anti-inflammatory activity and an IC50 value of 3.55 nM. Zabedosertib (BAY 1834845) exhibits anti-inflammatory property against IL-β, LPS and Imiquimod induced inflammation. |
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