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KL-11743 is a potent, orally active, and glucose-competitive inhibitor of the class I glucose transporters, with IC50s of 115, 137, 90, and 68 nM for GLUT1, GLUT2, GLUT3, and GLUT4, respectively. KL-11743 specifically blocks glucose metabolism. KL-11743 can synergize with electron transport inhibitors to induce cell death.
| Molecular Weight | 522.6 |
| Formula | C30H30N6O3 |
| CAS Number | 1369452-53-8 |
| Form | Solid |
| Solubility (25°C) | DMSO 25 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related GLUT Products |
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| STF-31
STF-31 is a selective glucose transporter GLUT1 inhibitor, with an IC50 of 1 μM. STF-31 is also a NAMPT inhibitor. |
| WZB117
WZB117 is an inhibitor of Glucose Transporter 1 (GLUT1). It inhibited cell proliferation in lung cancer A549 cells and breast cancer MCF7 cells with an IC50 of approximately 10 μM. |
| 1,9-Dideoxyforskolin
1,9-Dideoxyforskolin is a inactive analog of forskolin |
| Dihydrokainic acid
Dihydrokainic acid is a selective inhibitor of the GLT-1 glutamate transporter. |
| BAY-876
BAY-876 is a potent, highly selective, cell-permeable inhibitor of glucose transporter GLUT1 with an IC50 of 2 nM. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis. |
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Products are for research use only. Not for human use. We do not sell to patients.
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