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Kevetrin activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis.Kevetrin has demonstrated potent anti-tumor efficacy against various carcinoma xenograft models: lung, breast, colon, prostate and squamous cell carcinoma, and in a leukemia tumor model. In drug-resistant cell lines, Kevetrin has shown excellent activity, galvanizing the Company to focus on Kevetrin's development potential in this area.
| Molecular Weight | 179.67 |
| Formula | C5H10ClN3S |
| CAS Number | 66592-89-0 |
| Solubility (25°C) | Water 60 mg/mL DMSO 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related p53 Products |
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| Tenovin-1
Tenovin-1 is a small molecule activator of p53 transcriptional activity. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also a dihydroorotate dehydrogenase (DHODH) inhibitor. |
| Pifithrin-α
Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. |
| JNJ-26854165
JNJ-26854165 (Serdemetan) is a novel activator of p53 capable of inducing apoptosis in cancer cell lines. |
| Inauhzin
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| Tenovin-6
Tenovin-6 is a small molecule activator of p53 transcriptional activity. |
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Products are for research use only. Not for human use. We do not sell to patients.
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