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K-8794

Cat. No. M40488

All AbMole products are for research use only, cannot be used for human consumption.

K-8794 Structure

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Quality Control & Documentation
Biological Activity

K-8794 is an endothelin receptor ETB antagonist that may be used in studies related to heart failure.

Chemical Information
Molecular Weight 682.8
Formula C36H38N6O6S
CAS Number 319017-56-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Nobutake Sadamasa et al. J Neurosurg. Cerebral aneurysm progression suppressed by blockage of endothelin B receptor

[2] Koh-ichi Sugimoto et al. J Cardiovasc Pharmacol. Renal protective effect of YM598, a selective endothelin type A receptor antagonist

[3] M Sawaki et al. J Cardiovasc Pharmacol. Chronic effects of an orally active selective endothelin-B-receptor antagonist in experimental congestive heart failure

Related Endothelin Receptor Products
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Zibotentan (ZD4054) is a more selective and specific endothelin-A receptor (ETAR) antagonist with an IC50 value of 21 nM.

Ambrisentan

Ambrisentan is an orally active, highly selective antagonist of the endothelin-1 type A receptor.

Sitaxsentan sodium

Sitaxsentan (TBC-11251) is an orally active, highly selective antagonist of endothelin A receptors.

Macitentan

Macitentan is an orally-active, tissue-targeting dual ET receptor antagonist.

Bosentan Hydrate

Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.

  Catalog
Abmole Inhibitor Catalog




Keywords: K-8794 supplier, Endothelin Receptor, inhibitors, activators

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