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JZP-MA-11 is a positron emission tomography (PET) ligand targeting the endocannabinoid α/β-hydrolase domain 6 (ABHD6) enzyme. JZP-MA-11 selectively inhibits ABHD6 with an IC50 value of 126 nM. JZP-MA-11 can cross the blood-brain barrier (BBB). [18F]JZP-MA-11 has the potential for preclinical evaluation targeting the brain ABHD6 in mice and nonhuman primate (NHP).
| Molecular Weight | 336.38 |
| Formula | C15H17FN4O2S |
| CAS Number | 1672691-50-7 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
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JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM. |
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| JW 642
Jw642 is a highly effective selective monoacylglycerol lipase (MAGL) inhibitor with IC50 of 7.6 nM, 14 nM and 3.7 nM in mouse, rat and human meninges, respectively. |
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