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JWG-071 is the first reported kinase-selective chemical probe for ERK5, inhibits ERK5 and LRRK2 with IC50 of 88 and 109 nM, respectively. JWG-071 improves ERK5 activity and BRD4 selectivity.
| Molecular Weight | 612.76 |
| Formula | C34H44N8O3 |
| CAS Number | 2250323-50-1 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related ERK Products |
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SCH772984 is a novel and selective inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. |
| FR 180204
FR 180204 is an ATP-competitive, selective ERK inhibitor with Ki of 0.31 μM and 0.14 μM for ERK1 And ERK2, respectively. |
| GDC-0994
Ravoxertinib (GDC-0994) is an orally active ERK kinase inhibitor with IC50 of 6.1 nM and 3.1 nM against ERK1 and ERK2, respectively. |
| Astragaloside IV
Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine. It has various effect on the cardiovascular, immune, digestive, and nervous systems. |
| Corynoxeine
Corynoxeine, isolated from the hook of Uncaria Rhynchophylla, is a potent ERK1/ERK 2 inhibitor in the proliferation of PDGF-BB induced vascular smooth muscle cells (VSMCs). |
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