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JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis.
| Molecular Weight | 518.6 |
| Formula | C30H34N2O6 |
| CAS Number | 1255303-54-8 |
| Form | Solid |
| Storage | 4°C, protect from light, dry, sealed |
| Related CSF-1R (c-Fms) Products |
|---|
| GW2580
GW2580 is a selective CSF-1R inhibitor for c-FMS with IC50 of 30 nM, 150- to 500-fold selective compared to b-Raf, CDK4, c-KIT, c-SRC, EGFR, ERBB2/4, ERK2, FLT-3, GSK3, ITK, JAK2 etc. |
| PLX647
PLX647 is a highly specific dual FMS/KIT kinase inhibitor with IC50 of 28/16 nM respectively. |
| BLZ945 (Sotuletinib)
Sotuletinib (BLZ945) is an orally active, potent and selective CSF-1R inhibitor with IC50 of 1 nM, >1000-fold selective against its closest receptor tyrosine kinase homologs. |
| Ki 20227
Ki 20227 is a c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation. |
| PLX5622
PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor with an Ki of 5.9 nM. |
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Products are for research use only. Not for human use. We do not sell to patients.
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